TY - JOUR
T1 - The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting
AU - Metafuni, E.
AU - Di, Marino L.
AU - Giammarco, S.
AU - Bellesi, S.
AU - Limongiello, M. A.
AU - Sora', Federica
AU - Frioni, F.
AU - Maggi, R.
AU - Chiusolo, Patrizia
AU - Sica, Simona
PY - 2023
Y1 - 2023
N2 - Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current knowledge about the close link between microbiota and allogeneic stem cell transplantation setting. The PubMed search engine was used to perform this review. We analyzed data on microbiota dysbiosis related to the above-mentioned affecting factors. We also looked at treatments aimed at modifying gut dysbiosis and applications of fecal microbiota transplantation in the allogeneic stem cell transplant field, with particular interest in fecal microbiota transplantation for graft-versus-host disease (GvHD), multidrug-resistant and clostridium difficile infections, and microbiota restoration after chemotherapy and antibiotic therapy.
AB - Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current knowledge about the close link between microbiota and allogeneic stem cell transplantation setting. The PubMed search engine was used to perform this review. We analyzed data on microbiota dysbiosis related to the above-mentioned affecting factors. We also looked at treatments aimed at modifying gut dysbiosis and applications of fecal microbiota transplantation in the allogeneic stem cell transplant field, with particular interest in fecal microbiota transplantation for graft-versus-host disease (GvHD), multidrug-resistant and clostridium difficile infections, and microbiota restoration after chemotherapy and antibiotic therapy.
KW - allogeneic hematopoietic stem cell transplantation
KW - clostridium difficile infection
KW - diversity
KW - fecal microbiota transplantation
KW - graft-versus-host disease
KW - multi-drug resistant
KW - prebiotic
KW - probiotic
KW - allogeneic hematopoietic stem cell transplantation
KW - clostridium difficile infection
KW - diversity
KW - fecal microbiota transplantation
KW - graft-versus-host disease
KW - multi-drug resistant
KW - prebiotic
KW - probiotic
UR - https://publicatt.unicatt.it/handle/10807/262740
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85172809430&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85172809430&origin=inward
U2 - 10.3390/microorganisms11092182
DO - 10.3390/microorganisms11092182
M3 - Article
SN - 2076-2607
VL - 11
SP - N/A-N/A
JO - Microorganisms
JF - Microorganisms
IS - 9
ER -