TY - JOUR
T1 - The radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer: A multidisciplinary vulcan team review
AU - Tagliaferri, Luca
AU - Lancellotta, V.
AU - Casa, C.
AU - Fragomeni, S. M.
AU - Ferioli, M.
AU - Gentileschi, Stefano
AU - Caretto, A. A.
AU - Corrado, G.
AU - Gui, B.
AU - Colloca, G. F.
AU - Gambacorta, Maria Antonietta
AU - Morganti, A. G.
AU - Garganese, Giorgia
AU - Macchia, G.
PY - 2021
Y1 - 2021
N2 - Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisci-plinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.
AB - Locally advanced vulvar cancer (LAVC) is a challenging disease, requiring multidisci-plinary management. The aim of this review is to propose an integrated clinical approach including radiotherapy (RT) in the multidisciplinary management of LAVC to customize the treatment. A review of the literature was conducted on PubMed, Scopus, and Cochrane library to acquire all relevant studies on RT in LAVC. Based on the available evidence, RT, with or without concurrent chemotherapy, has a relevant role as adjuvant and exclusive treatment or in the neoadjuvant setting. However, multicentric prospective trials are needed to define the best treatment options based on tumor and patient characteristics. A multidisciplinary and multidimensional assessment can also be useful to identify the most suitable approach, considering patients’ age and comorbidities, in view of a better treatment personalization.
KW - Radiotherapy
KW - Review
KW - Vulvar cancer
KW - Radiotherapy
KW - Review
KW - Vulvar cancer
UR - https://publicatt.unicatt.it/handle/10807/203182
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85119078097&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85119078097&origin=inward
U2 - 10.3390/cancers13225747
DO - 10.3390/cancers13225747
M3 - Article
SN - 2072-6694
VL - 13
SP - 5747
EP - 5765
JO - Cancers
JF - Cancers
IS - 22
ER -
