FLT3 Mutated Acute Myeloid Leukemia after CD19 CAR-t Cells

Despite advancements in Chimeric Antigen Receptor T-cell (CAR-T) therapy and its notable successes, relapses and non-relapse mortality (NRM) still significantly affect prognosis. These factors contribute to the ongoing complexities in achieving favorable outcomes for patients undergoing CAR-T treatment. Secondary leukemias represent a potential complication that may manifest subsequent to CAR-T treatment. Overall, secondary leukemia may account for mutations in the FLT3 gene. These mutations can induce uncontrolled proliferation of blood cells, thereby fostering the development of aggressive and refractory forms of leukemia.