Allogenic Cord Blood Transfusion in Preterm Infants

Luciana Teofili; Patrizia Papacci; C. Giannantonio; M. Bianchi; Valentini C. Giovanna; Giovanni Vento

doi:10.1016/j.clp.2023.07.005

Allogenic Cord Blood Transfusion in Preterm Infants

Luciana Teofili^*, Patrizia Papacci, C. Giannantonio, M. Bianchi, Valentini C. Giovanna, Giovanni Vento

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

: Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

Lingua originale	English
pagine (da-a)	881-893
Numero di pagine	13
Rivista	Clinics in Perinatology
Volume	50
Numero di pubblicazione	4
DOI	https://doi.org/10.1016/j.clp.2023.07.005
Stato di pubblicazione	Pubblicato - 2023

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

Keywords

Blood product
Cord blood
Fetal hemoglobin
Oxidative stress
Preterm neonates

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10.1016/j.clp.2023.07.005

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abstract = ": Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.",

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author = "Luciana Teofili and Patrizia Papacci and C. Giannantonio and M. Bianchi and Giovanna, {Valentini C.} and Giovanni Vento",

year = "2023",

doi = "10.1016/j.clp.2023.07.005",

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T1 - Allogenic Cord Blood Transfusion in Preterm Infants

AU - Teofili, Luciana

AU - Papacci, Patrizia

AU - Giannantonio, C.

AU - Bianchi, M.

AU - Giovanna, Valentini C.

AU - Vento, Giovanni

PY - 2023

Y1 - 2023

N2 - : Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

AB - : Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

KW - Blood product

KW - Cord blood

KW - Fetal hemoglobin

KW - Oxidative stress

KW - Preterm neonates

KW - Blood product

KW - Cord blood

KW - Fetal hemoglobin

KW - Oxidative stress

KW - Preterm neonates

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ER -

Allogenic Cord Blood Transfusion in Preterm Infants

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

Accesso al documento

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