TY - JOUR
T1 - CAR-T treatment is safe and effective in adult patients with Down syndrome and B-cell acute lymphoblastic leukemia (B-ALL)
AU - Galli, E.
AU - Corrente, A.
AU - Chiusolo, Patrizia
AU - Sica, Simona
AU - Sora', Federica
PY - 2024
Y1 - 2024
N2 - We reviewed data from PubMed including both randomized and real-life studies filtering for “CAR-T” and “acute lymphoblastic leukemia” between January 2018 and May 2024. We reviewed 90 papers, among which only 4 reported data on 18 DS patients (age 3-21 years) with B-ALL treated with CAR-T (tisa-cel in 17 patients, a CD19.28zeta-CAR T in 1 patient) [1, 14, 15]. In all studies, the authors observed no differences in overall response rate and early and late CAR-T toxicities between patients with or without DS. Adult patients with DS were admitted in the ZUMA-3 trial with KTE-X19, but specific data on those patients are not disclaimed by the authors.\r\n\r\nHere, we present two cases of adult patients with DS (summarized in Table 1) affected by B-ALL safely treated with brexucabtagene autoleucel, based on data reported in the ZUMA-3 trial.
AB - We reviewed data from PubMed including both randomized and real-life studies filtering for “CAR-T” and “acute lymphoblastic leukemia” between January 2018 and May 2024. We reviewed 90 papers, among which only 4 reported data on 18 DS patients (age 3-21 years) with B-ALL treated with CAR-T (tisa-cel in 17 patients, a CD19.28zeta-CAR T in 1 patient) [1, 14, 15]. In all studies, the authors observed no differences in overall response rate and early and late CAR-T toxicities between patients with or without DS. Adult patients with DS were admitted in the ZUMA-3 trial with KTE-X19, but specific data on those patients are not disclaimed by the authors.\r\n\r\nHere, we present two cases of adult patients with DS (summarized in Table 1) affected by B-ALL safely treated with brexucabtagene autoleucel, based on data reported in the ZUMA-3 trial.
KW - Acute Lymphoblastic Leukemia
KW - Brexucabtagene Autoleucel
KW - CAR-T
KW - Down Syndrome
KW - Acute Lymphoblastic Leukemia
KW - Brexucabtagene Autoleucel
KW - CAR-T
KW - Down Syndrome
UR - https://publicatt.unicatt.it/handle/10807/295380
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85200941772&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85200941772&origin=inward
U2 - 10.1038/s41409-024-02386-0
DO - 10.1038/s41409-024-02386-0
M3 - Article
SN - 0268-3369
SP - N/A-N/A
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 08
ER -
