TY - JOUR
T1 - CAR-T from cord blood in a patient with Ph+ acute lymphoblastic leukemia relapsing after hematopoietic stem cell transplantation
AU - Marra, J. D.
AU - Galli, E.
AU - Giammarco, S.
AU - Metafuni, E.
AU - Minnella, G.
AU - Fosso, F.
AU - Marietti, S.
AU - Sica, Simona
AU - Sora', Federica
AU - Chiusolo, Patrizia
PY - 2024
Y1 - 2024
N2 - While there is intense interest in the production of allogeneic CAR-T cells from umbilical cord units, little is known about the reactivity and persistence of CAR-T cells of umbilical origin. We report the case of a patient at our hematological center with multiple relapsing Ph+ B-ALL, notably a Blinatunomab non-responder, who underwent therapy with Brexucabtagene Autoleucel following relapse on Ponatinib post-allogeneic hematopoietic stem cell transplantation. The patient achieved a rapid CAR-T expansion and durable remission presenting in good clinical conditions 6 months post-CAR-T infusion, without manifestations of graft-versus-host disease. The case report provides insight into the reactivity and persistence of CAR-T cells of umbilical origin, confirming the potential promise of allogeneic umbilical cord-derived CAR-T cells.
AB - While there is intense interest in the production of allogeneic CAR-T cells from umbilical cord units, little is known about the reactivity and persistence of CAR-T cells of umbilical origin. We report the case of a patient at our hematological center with multiple relapsing Ph+ B-ALL, notably a Blinatunomab non-responder, who underwent therapy with Brexucabtagene Autoleucel following relapse on Ponatinib post-allogeneic hematopoietic stem cell transplantation. The patient achieved a rapid CAR-T expansion and durable remission presenting in good clinical conditions 6 months post-CAR-T infusion, without manifestations of graft-versus-host disease. The case report provides insight into the reactivity and persistence of CAR-T cells of umbilical origin, confirming the potential promise of allogeneic umbilical cord-derived CAR-T cells.
KW - CAR-T
KW - acute lymphoblastic leukemia
KW - cord blood transplantation
KW - CAR-T
KW - acute lymphoblastic leukemia
KW - cord blood transplantation
UR - https://publicatt.unicatt.it/handle/10807/295558
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85191157279&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85191157279&origin=inward
U2 - 10.1111/ejh.14217
DO - 10.1111/ejh.14217
M3 - Article
SN - 0902-4441
VL - 113
SP - 127
EP - 129
JO - European Journal of Haematology
JF - European Journal of Haematology
IS - 1
ER -
