Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management

John Donald Marra; Filippo Frioni; Gessica Minnella; Monica Rossi; Tanja Malara; Silvia Bellesi; Elena Maiolo; Daniela Orteschi; Eugenio Galli; Andrea Bacigalupo; Livio Pagano; Simona Sica; Gina Zini; Patrizia Chiusolo

doi:10.1007/s00277-023-05561-3

Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management

John Donald Marra, Filippo Frioni, Gessica Minnella, Monica Rossi, Tanja Malara, Silvia Bellesi, Elena Maiolo, Daniela Orteschi, Eugenio Galli, Andrea Bacigalupo, Livio Pagano, Simona Sica^*, Gina Zini, Patrizia Chiusolo

^*Corresponding author

Research output: Contribution to journal › Article

Abstract

A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Annals of Hematology
Volume	103
Issue number	3
DOIs	https://doi.org/10.1007/s00277-023-05561-3
Publication status	Published - 2024

All Science Journal Classification (ASJC) codes

Hematology

Keywords

Acute erythroid leukemia
BCR-ABL
Classification
TP53

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00277-023-05561-3

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title = "Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management",

abstract = "A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient{\textquoteright}s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.",

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AU - Marra, John Donald

AU - Frioni, Filippo

AU - Minnella, Gessica

AU - Rossi, Monica

AU - Malara, Tanja

AU - Bellesi, Silvia

AU - Maiolo, Elena

AU - Orteschi, Daniela

AU - Galli, Eugenio

AU - Bacigalupo, Andrea

AU - Pagano, Livio

AU - Sica, Simona

AU - Zini, Gina

AU - Chiusolo, Patrizia

PY - 2024

Y1 - 2024

N2 - A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.

AB - A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.

KW - Acute erythroid leukemia

KW - BCR-ABL

KW - Classification

KW - TP53

KW - Acute erythroid leukemia

KW - BCR-ABL

KW - Classification

KW - TP53

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Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management

Abstract

All Science Journal Classification (ASJC) codes

Keywords

UN SDGs

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